Denkyembour District is one of the 254 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana and forms part of the thirty three 33 Municipalities and Districts in the Eastern Region of Ghana.

With its Administrative capital Akwatia was carved from Kwaebibirem and forms part of the new districts and municipalities created in the year 2012 and were inaugurated at their various locations simultaneously on the 28th June, 2012.

Established by a Legislative Instrument (LI) 2042, the Denkyembuor District is located at the South-Western corner of the Eastern Region.

The District shares boundaries with Kwaebibirem Municipal and Akyemansa District to the north, West Akim Municipality to the south and Birim Central Municipality to the south-west.

The population of the District according to 2010 population and housing census stands at 78,841 with 38,814 males and 40,027 females.