The Daffiama-Bussie-Issa District is one of the 261 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the 11 of Municipalities and Districts in the Upper West Region.

The Daffiama Bussie Issa District was part of the Nadowli District, which was established by the District Assemblies Law 1988 (Republic of Ghana, 1988). The Daffiama Bussie Issa District was carved out of the erstwhile Nadowli District in 2012 through Legislative Instrument 2100 with Issa as the capital (Republic of Ghana, 2012).

The District is centrally located in the Upper West Region of Ghana and lies between Latitudes 11o 30" and 10o 20" north and Longitudes 3o 10" and 2o 10" west.

In terms of size, it covers a total land area of 1,414 square kilometres and extends from the Billi Bridge (four kilometres from Wa) to the Dapuori Bridge (almost 28 kilometres from Nadowli) on the main Wa-Tumu Road and also from west to east it extends from the Black Volta to Daffiama Issa, the district capital, is 57 kilometres from the regional capital, Wa.

It is bordered on the south by the Wa Municipality, west by the Nadowli Kaleo District, north by the Sissala West District and east by the Wa East District.

The population of the District according to 2021 population and housing census stands at 38,754 with 18,923 males and 19,831 females.