The Nkwanta South Municipal is one of the 261 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the 8 of Municipalities and Districts in the Oti Region.

The Municipality is located in the northern - most part of the Region. It lies between latitudes 7 30° and 8 45° North and longitude 0 10° and 0 45°. The District has a surface area of approximately 2473 km2 East. Nkwanta South Municipal was carved out of Krachi West District in 1989. The Administrative Capital of the Municipal is Nkwanta.

The Municipal is bounded to the north by the Nkwanta North District, to the south by the Kadjebi District, to the east by the Republic of Togo and to the west by  Krachi East District.

The population of the Municipality according to 2021 population and housing census stands at 135,936  with 68,143 males and 67,793 females.