The Pusiga District is one of the 261 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the fifteen (15) Municipalities and Districts in the Upper East Region.

It was carved out of the then Bawku Municipality in 2012 by Legislative Instrument, LI 2145 with its administrative capital Pusiga

The District is located approximately between latitude 110 111 and 100 401 north and longitude 00 18 1 W and 00 61 E in the north-eastern corner of the Region and has a total land size of about 50505 sq km.

The District covers a total land area of 260 square kilometres.

The District shares boundaries with Burkina Faso to the north, Republic of Togo to the east, Bawku Municipality to the west and Garu District to the south. 

The population of the District according to 2021 population and housing census stands at 80,533 with 38,769 males and 41,764 females.