The Akatsi South Municipal is one of the 261 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the 18 of Municipalities and Districts in the Volta Region.

The Municipality which is located in the south-eastern part of the Volta Region was elevated from a District to a municipality on the 5th October 2020 with LI 2420 . It has a total land area of about 960.445 sq. km, the total land under cultivation is about 51,438.12 hectares. The Municipality is located between latitude 6° S - 7° North 0° W - 1 ° W.  Akatsi is the administrative capital.

The Municipality is bounded to the south by the Keta Municipal, to the east by the Ketu North Municipal, to the north by North Tongu District to the west, Agotime Ziope District and the Republic of Togo to complete the demarcation of the Akatsi Municipal.

The population of the Municipality according to 2010 population and housing census stands at 95,426 with 44,039 males and 51,387 females.