Ahafo Ano South East District is one of the forty three (43) administrative Metropolitan, Municipalities and Districts in the Ashanti Region of Ghana. The district capital, Mankranso is located about 34 kilometres north-west of Kumasi on the Kumasi-Sunyani highway.

The district was part of the former Ahafo Ano District Council and was created under Legislative Instrument 1401.

The Ahafo Ano South East District covers a total surface area of about 1190.7 km2, representing 4.9 percent of the region’s total surface area.

The Ahafo Ano South District is located on latitude 6°42' north and longitude 1°45'N and 2°20'W. It is located on the north-western part of the Ashanti Region.

It is bounded to the north-east by Tano North Municipal of the Brong Ahafo Region, north-west by Ahafo Ano North Municipal, to the south by Atwima Nwabiagya District, and to the east by the Offinso North District all in the Ashanti Region. 

The population of the District in 2010, according to the 2010 Population and Housing Census, is 121,659. Males constitute 50.8 percent and females represent 49.2 percent.