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The Daffiama-Bussie-Issa District was part of the Nadowli District, which was established by the District Assemblies Law 1988 (Republic of Ghana, 1988). The Daffiama-Bussie-Issa District was carved out of the erstwhile Nadowli District in 2012 through Legislative Instrument 2100 with Issa as the capital (Republic of Ghana, 2012).

The district is centrally located in the Upper West Region of Ghana and lies between Latitudes 11o 30" and 10o 20" North and Longitudes 3o 10" and 2o 10" West. It is bordered on the south by the Wa Municipality, west by the Kaleo-Nadowli District, north by the Sissala West District and east by the Wa East District.

In terms of size, it covers a total land area of 1,315.5 square kilometres and extends from the Billi Bridge (four kilometres from Wa) to the Dapuori Bridge (almost 28 kilometres from Nadowli) on the main Wa-Tumu Road and also from west to east it extends from the Black Volta to Daffiama Issa, the district capital, is 57 kilometres from the regional capital, Wa.